科研项目: 1.国家自然科学基金，地区科学基金项目，32460914，巨噬细胞囊泡运输蛋白Sec22B调控鼠伤寒沙门氏菌胞内生存的作用机制研究，202501至202812，32万元，在研，主持。 2.海南省科学技术厅，高层次人才项目，823RC468，外膜囊泡载带sRNA调控鸡白痢沙门氏菌侵染宿主细胞的分子调控机制研究，202303至202602，8万元，已结题，主持。 3.海南省科学技术厅，高层次人才项目，2019RC021，鼠伤寒沙门氏菌SPI2毒力岛关键效应分子ExoS蛋白的功能及其互作蛋白的筛选鉴定，2020-01至2022-12，10万元，已结题，主持。 代表性学术论文： 1. Meihong Fu; Yuling Sun; Yingquan Wu; Nanlong Zhou; Meiling Huang; Tiansen Li*; Molecular Strategies of Salmonella Typhimurium: From Host Cell Invasion and Metabolic Hijacking to Immune Evasion[J], Frontiers in Cellular and Infection Microbiology, 2026, 03. 2.Ting He, Yonghui Ding, Yuling Sun and Tiansen Li*; Advances in sRNA-mediated regulation of Salmonella infection in the host[J], Frontiers in Cellular and Infection Microbiology, 2025.05. 3.He, Ting; Huang, Meiling; Sun, Yuling; Ding, Yonghui; Zhou, Nanlong; Fu, Meihong; Li,Tiansen*; A newly discovered sRNA is involved in the virulence regulation of Salmonella pullorum[J], Frontiers in Veterinary Science, 2025, 12. 4. Zhou Nanlong†, Ding Yonghui†, He Ting; Sun Yuling; Chen Hongfang; Huang Meiling and Li Tiansen*; Characterization and Protective Efficacy of a Salmonella Typhimurium ATCC 14028 sptP Mutant as a Live Attenuated Vaccine Candidate[J]. Vaccines, 2025.01. 5.Yueli WANG, Zhongchen MA, Huan ZHANG, Jihai YI, Yong WANG, Tiansen Li*, Chuangfu CHEN, The Deletion of Omp19 Gene of Brucella abortus 2308 Reduces Its Survival in Mouse Macrophage and in Mice[J]. Kafkas Univ Vet Fak Derg, 2020, 07. 6. Yihai YI; Yueli WANG; Xiaoyu DENG; Zhiran SHAO; Huan ZHANG; Benben WANG; Tiansen Li; Chuangfu CHEN, The Role of JAK2/STAT3 Signaling Pathway Regulation in Macrophage Apoptosis During Brucella M5-90 Infection[J]. Kafkas Univ Vet Fak Derg, 2018, 05 1 6.Li Tiansen; Xu Yafang; chen Chuangfu; Brucella Melitensis 16M Regulates the Effect of AIR Domain on Inflammatory Factors, Autophagy, and Apoptosis in Mouse Macrophage through the ROS Signaling Pathway[J], Plos One, 2016. 7.Li Tiansen; Song Zhanhui; Zhang Hui; Chen Chuangfu; Biological characteristics and conju gated antigens of ClfA A-FnBPA and CP5 in Staphylococcus aureus[J], canadian Journal of Veterinary Research, 2018. 8.Zhangyu†; Li Tiansen†; Zhang Hui; The Brucella melitensis M5-90 phosphoglucomutase (PGM) muattenuated and confers protection against wild-type challenge in BALB/c mice[J], World J Micr obiol Biotechnology, 2016. 9.Li Tiansen†; Huang Meiling†; Zhang Hui; Chen Chuangfu; Construction and characteristic ana lysis of Omp10 deletion mutant of Brucella abortu[J]s, Pakistan Journal of Zoology.2017, 10.Li Tiansen; Tong Zhixia; Huang Meiling; Tang Liyan; Zhang Hui; Chen Chuangfu; Brucella melitensis M5-90 Delta bp26 as a potential live vaccine that allows for the distinction between na tural infection and immunization[J], Canadian Journal of Microbiology, 2017. | 