研究成果 | 科研项目: 1. 国家自然科学基金委员会，地区基金项目，32360878，花生四烯酸及代谢产物经PPAR-γ通路调控文昌鸡沙门氏菌性肠炎的作用机制研究，2024/01-2027/12，32 万元，在研，主持 2. 国家自然科学基金委员会，青年基金项目，31502098，轮状病毒 VP4、VP7及细胞网格蛋白、动力蛋白在病毒侵入晚期过程中的作用，2015/01-2018/12，18 万元，已结题，主持 3. 国家自然科学基金委员会，地区合作交流项目，31310103031，细胞内模式识别受体 MDA-5 表达对牛UK株轮状病毒增殖的影响，2013/04-2013/12，2 万元，已结题，主持 4. 海南省科学技术厅，海南省自然科学基金高层次人才项目，325RC673，花生四烯酸环氧合酶代谢途径调控禽巨噬细胞沙门 氏菌性炎症的通路及机制研究，2025/03-2028/02，10 万元，在研，主持 5. 海南省科学技术厅，海南省自然科学基金高层次人才项目，321RC1020，禽沙门氏菌感染与海南文昌鸡盲肠菌群失调及菌群重建的相关性分析，2021/12-2024/09，8 万元，已结题，主持 6. 永利yl7703主页科研启动项目，RZ2100003064、禽肠道菌群稳定性与肠道免疫器官发育及黏膜免疫应答调控的机制研究、2021/05-2026/05、100万元、在研、主持。 7. 黑龙江省青年科学基金项目，QC2013C028，siRNA 抑制 Caco-2 细胞网格蛋白表达对轮状病毒侵入影响，2014/01-2016/12，5 万元，已结题，主持 8. 黑龙江省教育厅面上项目，11521201，戊型肝炎ORF2的分段表达及其ELISA诊断方法的建立，2010/10-2013/03，1 万元，已结题，主持 9. 黑龙江省自然科学基金联合引导项目，LH2019C052，轮状病毒NSP2蛋白上决定病毒质形成的关键结构域的定位研究，2019/07-2022/07，10 万元，已结题，主持 学术论文： 1. Li X, Ma H, Huang J, Ran X*, Wen X*. Anti-Inflammatory Effects of Lipoxin A4 in Salmonella Typhimurium-Induced Enteritis in Wenchang Chickens [J]. Animals, 2026, 16(3): 504. 2. Zhang M, Huang J, Chi Q, Ran X*, Wen X*. Antiviral effects and mechanism of Ma-Xing-Shi-Gan-San on porcine reproductive and respiratory syndrome virus [J]. Front Microbiol, 2025, 16: 1539094. 3. Chen S, Xie Y, Guo D, Li T, Tan Z, Ran X*, Wen X*. Effects of Salmonella Typhimurium infection on intestinal flora and intestinal tissue arachidonic acid metabolism in Wenchang chickens [J]. Front Microbiol, 2025, 16: 1514115. 4. Liu Z, Zhao S, Jin X, Wen X*, Ran X*. Host and structure-specific codon usage of G genotype (VP7) among group A rotaviruses [J]. Front Vet Sci, 2024, 11: 1438243. 5. Hu Z, Huang J, Zhao S, Zhou H, Sun S, Wen X*, Ran X*. Development of a thermal stabilizer formulation optimized by response surface methodology for Senecavirus A antigen [J]. J Pharm Sci, 2024, 114(2): 1024-1034. 6. Ran X, Hu Z, Wang J, Yang Z, Li Z, Wen X*. Prevalence of Senecavirus A in pigs from 2014 to 2020: a global systematic review and meta-analysis [J]. J Vet Sci, 2023, 24(3): e48. 7. Zhao S M, Cui H Q, Hu Z R, Du L, Ran X H*, Wen X B*. Senecavirus A Enhances Its Adaptive Evolution via Synonymous Codon Bias Evolution [J]. Viruses, 2022, 14(5): 1055. 8. Zhao S, Jin X, Zang L, Liu Z, Wen X*, Ran X*. Global Infection Rate of Rotavirus C during 1980-2022 and Analysis of Critical Factors in the Host Range Restriction of Virus VP4 [J]. Viruses, 2022, 14(12): 2826. 9. Lv Q†, Ran X†, Qiu H, Zhao S, Hu Z, Wang J, Ni H, Wen X*. Seroprevalence of pullorum disease in chicken across mainland China from 1982 to 2020: A systematic review and meta-analysis [J]. Res Vet Sci, 2022, 152: 156-166. 10. Yang Y, Teng Z, Lu Y, Luo X, Mu S, Ru J, Zhao X, Guo H, Ran X, Wen X*, Sun S*. Enhanced immunogenicity of foot and mouth disease DNA vaccine delivered by PLGA nanoparticles combined with cytokine adjuvants [J]. Res Vet Sci, 2021, 136: 89-96. 11. Wen X, Tong X, Wang M, Wang J, Ni H, Ran X*. Protective immunity following vaccination with a recombinant multiple-epitope protein of bovine herpesvirus type I in a rabbit model [J]. Appl Microbiol Biotechnol, 2020, 104: 3011-3023. 12. Ni H, Jia X X, Wang J, Ran X, Wen X*. Mapping a highly conserved linear neutralizing epitope at the N-terminus of the gD glycoprotein of bovine herpesvirus type I using a monoclonal antibody [J]. Microb Pathog, 2020, 138: 103815. 13. Ran X, Yang Z, Bai M, Zhang Y, Wen X, Guo H, Sun S*. Development and validation of a competitive ELISA based on bacterium-original virus-like particles of serotype O foot-and-mouth disease virus for detecting serum antibodies [J]. Appl Microbiol Biotechnol, 2019, 2019, 103(7): 3015- 3024. 14. Ran X, Cheng J, Wang M, Chen X, Wang H, Ge Y, Ni H, Zhang X X*, Wen X*. Brucellosis seroprevalence in dairy cattle in China during 2008-2018: A systematic review and meta-analysis [J]. Acta Trop, 2019, 189:117-123. 15. Ran X, Chen X, Wang S, Chang C, Wen X, Zhai J, Ni H*. Preparation of porcine enterotoxigenic Escherichia coli (ETEC) ghosts and immunogenic analysis in a mouse model [J]. Microb Pathog, 2019, 126:224-230. 16. Ran X†, Chen X†, Ma L, Wen X, Zhai J, Wang M, Tong X, Hou G, Ni H*. A systematic review and meta-analysis of the epidemiology of bovine viral diarrhea virus (BVDV) infection in dairy cattle in China [J]. Acta Trop, 2019, 190:296-303. 17. Ran X, Chen X, Wang M, Cheng J, Ni H, Zhang X X*, Wen X*. Brucellosis seroprevalence in ovine and caprine flocks in China during 2000-2018: a systematic review and meta-analysis [J]. BMC Vet Res, 2018, 14(1): 393. 18. Ran X, Yang Z, Shao G, Wen X, Liu s, Ni H*. Avian Salmonella enteritidis serovar Enteritidis with ClpP deletion is attenuated and highly immunogenic in chickens [J]. Turk J Vet Anim Sci, 2018, 42: 269-276. 19. Wen X, Wei X, Ran X*, Ni H, Cao S, Zhang Y. Immunogenicity of porcine P[6], P[7]-specific truncated VP8* rotavirus subunit vaccines with a tetanus toxoid universal T cell epitope [J]. Vaccine, 2015, 33(36): 4533-4539. 20. Ran X†, Meng X Z†, Geng H L, Chang C, Chen X, Wen X*, Ni H*. Generation of porcine Pasteurella multocida ghost vaccine and examination of its immunogenicity against virulent challenge in mice [J]. Microb Pathog, 2019, 132:208-214. 21. Li Z, Liu D, Ran X, Liu C, Guo D, Hu X, Tian J, Zhang X, Shao Y, Liu S*, Qu L. Characterization and pathogenicity of a novel mammalian orthoreovirus from wild short-nosed fruit bats [J]. Infect Genet Evol, 2016, 43:347-53. 22. Wang X, Bi Y, Ran X, Tong X, Ni H*, Wen X*. Mapping a highly conserved linear neutralizing epitope on gD glycoprotein of bovine herpesvirus type I using a monoclonal antibody [J]. J Vet Med Sci, 201. 著作教材： 1. 闻晓波, 冉旭华, 宋佰芬；轮状病毒，中国农业出版社，400千字，2013. |
