研究成果 | 科研项目: 1. 国家自然科学基金,青年基金项目(C类),32402926,鸭ZNRF3泛素化修饰H5N1亚型禽流感病毒蛋白进而调控病毒复制的作用机制研究,2025年1月~2027年12月,30万元,在研,主持; 2. 海南大学高层次人才科研启动经费项目,XJ2600000273,文昌鸡E3泛素连接酶影响禽流感病毒复制的作用机制研究,2025年5月~2030年5月,20万元,在研,主持; 3. 中国博士后科学基金,面上项目,2024M760978,鸭E3连接酶BTRC影响H5N1亚型禽流感病毒复制的作用机制研究,2024年1月~2025年4月,8万元,结题,主持; 4. 国家重点研发计划项目子课题,2021YFD1800202,华南地区禽流感病毒的宿主适应性机制研究,2021年1月~2025年12月,275万元,结题,参与; 5. 岭南现代农业科学与技术广东省实验室重大专项项目,NT2021007,新发/突发畜禽动物疫病的阻断技术研究,2021年1月~2025年12月,255万元,结题,参与; 6. 国家自然科学基金,面上项目,32072844,禽PIAS2蛋白与禽流感病毒RNP复合体组成蛋白相互作用而影响病毒复制的分子机制,2021年1月~2024年12月,58万元,结题,参与。
学术论文: 1. Zuxian Chen, Bingbing Zhao, Yingying Wang, Yuqing Du, Siyu Feng, Junsheng Zhang, Luxiang Zhao, Weiqiang Li, Yangbao Ding, Peirong Jiao. H5N1 avian influenza virus PB2 antagonizes duck IFN-β signaling pathway by targeting mitochondrial antiviral signaling protein. Journal of Integrative Agriculture. 2025;24(9): 3614-3625. 2. Zuxian Chen, Yingying Wang, Yating Song, Sumei Song, Zhuoliang He, Siyu Feng, Weiqiang Li, Yangbao Ding, Junsheng Zhang, Luxiang Zhao, Peirong Jiao. Duck MARCH8 Negatively Regulates the RLR Signaling Pathway through K29-Linked Polyubiquitination of MAVS. Journal of Immunology. 2023;210(6):786-794. 3. Zuxian Chen, Zhenyu Wang, Xiya Zhao, Yun Guan, Qian Xue, Jinrong Li, Zhiting Liu, Bingbing Zhao, Zhuoliang He, Jianni Huang, Ming Liao, Yafen Song, Peirong Jiao. Pathogenicity of different H5N6 highly pathogenic avian influenza virus strains and host immune responses in chickens. Veterinary Microbiology. 2020;246:108745. 4. Nannan Qu1, Bingbing Zhao1, Zuxian Chen1, Zhuoliang He, Weiqiang Li, Zhiting Liu, Xia Wang, Jianni Huang, You Zhang, Wanting He, Jie Sun, Zhifeng Qin, Ming Liao, Peirong Jiao. Genetic characteristics, pathogenicity and transmission of H5N6 highly pathogenic avian influenza viruses in Southern China. Transboundary and Emerging Diseases. 2019;66(6):2411-2425. 5. Junsheng Zhang, Qian Xue, Xiyi Wang, Huixing Yang, Minfan Huang, Meng Zhang, Luxiang Zhao, Wenqing Wang, Zuxian Chen, Peirong Jiao. Chicken PIAS2 enhances H6N2 avian influenza virus replication by promoting SUMOylation of viral NP. Veterinary Research. 2025;57(1):15. 6. Zhuoliang He, Weiqiang Li, Meng Zhang, Minfan Huang, Zuxian Chen, Xiya Zhao, Yangbao Ding, Junsheng Zhang, Luxiang Zhao, Peirong Jiao. RNF216 inhibits the replication of H5N1 avian influenza virus and regulates the RIG-I signaling pathway in ducks. Journal of Immunology 2024; 213, 187-203. 7. Weiqiang Li, Yu Lin, Xiyi Wang, Huixing Yang, Yangbao Ding, Zuxian Chen, Zhuoiliang He, Junsheng Zhang, Luxiang Zhao, Peirong Jiao. Chicken UFL1 Restricts Avian Influenza Virus Replication by Disrupting the Viral Polymerase Complex and Facilitating Type I IFN Production. Journal of immunology, 2024;212(9), 1479–1492. 8. Nianchen Wang, Minhua Sun, Wenqing Wang, Guowen Ouyang, Zuxian Chen, You Zhang, Bingbing Zhao, Siyu Wu, Jianni Huang, Hailiang Sun, Ming Liao, Peirong Jiao. Avian Influenza (H7N9) Viruses Co-circulating among Chickens, Southern China. Emerging infectious diseases. 2017;23(12), 2100-2102. 9.曲楠楠,陈祖贤,赵冰兵,刘伟强,刘智婷,王霞,何婉婷,瞿孝云,焦培荣.鸡TRIM25蛋白可促进宿主对禽流感病毒的天然免疫应答.中国科学:生命科学. 2018;48,1273-1278.
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