毕业院校

浙江大学

学  位

博 士

所属系

动物科学系

职  务

无

专业技术

职务

副教授

导师类别

博士生导师、硕士生导师

从事专业

动物营养与免疫学、畜禽健康高效养殖、植物天然活性成分功能分析

电子邮箱

hwzhang@hainanu.edu.cn

办公地址

海南省海口市人民大道58号永利yl7703主页国家重点实验室723

个人简介

永利yl7703主页抗生素替代型饲料添加剂研发创新培育团队负责人；海南省科协青年托举人才；海南省地方鸡产业体系核心成员。海南省E类人才，海南省三区科技人才，省级科技特派员。主要研究方向为天然饲用抗生素替代品及功能性饲料添加剂。先后主持国家自然科学基金项目、海南省重点研发项目、海南省高层次人才项目、海南省科协青年创新人才项目、海南省自然科学基金面上项目等各级项目8项。出版专（编）著1部，参编书籍3部，发表学术论文60余篇，部分研究成果发表在《International Journal of Biological Macromolecules》《Poultry Science》《Journal of Immunology》《Phytomedicine》《Journal of Agricultural and Food Chemistry》《Food & Function》《Molecular Pharmaceutics》《International Immunopharmacology》《Veterinary Immunology and Immunopathology》《Peptides》等国际期刊。所指导研究生2人获得国家奖学金，1人获得永利yl7703主页年度人物提名。所负责班级2021级动科2班研究生升学率达75%。获得永利yl7703主页优秀班主任、优秀学业导师、优秀本科毕业指导教师称号，获得三区科技人才基层服务工作年度考核优秀评价。

教育经历

2010年9月-2015年6月 浙江大学动物科技学院 饲料科学研究所 博士（硕博连读）

2006年9月-2010年6月 四川农业大学动物科技学院 动物科学专业 学士

工作经历

2015年7月-2018年12月 永利yl7703主页动物科技学院 讲师

2019年1月-至今 永利yl7703主页热带农林学院 副教授

研究方向

动物营养与免疫学、动物肠道营养调控、新型非常规饲料添加剂研发、植物天然活性成分提取及其构效关系、畜禽健康高效养殖技术。

研究成果

科研项目

1. 国家自然科学基金地区科学基金项目：Cathelicidin-BF（C-BF）抗菌肽调控mTORC1/HIF-1α和mTORC2/PPAR-γ介导五指山猪肠固有层巨噬细胞代谢重编程的机制研究，主持，在研，32万. 2026-01-01—2029-12-31.

2. 国家自然科学基金地区科学基金项目：猪源PR-39调控五指山猪肠道乳杆菌有机酸代谢保护肠黏膜屏障功能的分子机制，主持，在研，32万. 2023-01-01—2026-12-31.

3. 海南省重点研发项目：牛乳铁蛋白肽和蛋清溶菌酶的肽酶融合高效表达系统构建及其应用，主持，在研，30万.  2025-02-19—2028-02-18.

4. 海南省自然科学基金高层次人才项目：海南产辣木叶源多糖(MOLP)通过调控肠道菌群代谢影响文昌鸡体脂分配与沉积规律的机制研究，主持，在研，10万.  2025-03-01—2028-02-29.

5. 海南省高层次人才项目：海南紫大薯对热应激下育肥期文昌鸡脂质代谢的影响及作用机制，主持，已结题，8万. 2020-12-26—2023-12-25

6. 海南省林业局项目：海南省农业遗传资源调查，主持，已结题，10.8万. 2020-01-01—2023-12-31

7. 海南省教育厅教改项目：以实验动物学课程为介导搭建畜牧兽医专业学生多元化知识架构，主持，已结题，1.5万. 2020-01-01—2022-12-30

8. 海南省科协青年科技英才学术创新计划项目：基于畜禽减抗的动物源抗菌肽筛选及其作用机理研究，已结题，10万. 2018-05-01—2020-12-31

9. 海南省自然科学基金项目：抗菌肽对断奶仔猪肠道免疫的作用及调控机制，已结题，5万. 2016-01-01—2017-12-31

学术论文

1. Liu Z, Qin X, Zhang B, Nong K, Chen W, Yang Z, Lang W, Liu X, Li L, Wang X, Shi H, Zhang H. Proline rich-39 (PR-39) antimicrobial protein alleviated lipopolysaccharide-induced intestinal barrier dysfunction in piglets by altering intestinal flora associated bile acid metabolism and in turn regulating TGR-5/NF-κB/MLCK/MLC pathway. Int J Biol Macromol. 2025 Mar 10;307(Pt 1):141930. doi: 10.1016/j.ijbiomac.2025.141930. (中科院1区 TOP)

2. Lin M, Piao L, Zhao Z, Liao L, Wang D, Zhang H, Liu X. Therapeutic Potential of Cajanus cajan (L.) Millsp. Leaf Extract in Modulating Gut Microbiota and Immune Response for the Treatment of Inflammatory Bowel Disease. Pharmaceuticals (Basel). 2025 Jan 9;18(1):67. doi: 10.3390/ph18010067. PMID: 39861130; PMCID: PMC11769518.

3. Nong K, Qin X, Liu Z, Wang Z, Wu Y, Zhang B, Chen W, Fang X, Liu Y, Wang X, Zhang H. Potential effects and mechanism of flavonoids extract of Callicarpa nudiflora Hook on DSS-induced colitis in mice. Phytomedicine. 2024 Jun;128:155523. doi: 10.1016/j.phymed.2024.155523. (中科院1区 TOP).

4. Nong K, Liu Z, Qin X, Chen W, Zhang B, Wu Y, Wang Z, Fang X, Liu Y, Wang X, Shi H, Zhang H. Effect of the Pseudopleuronectes americanus-derived Pleurocidin on DSS-induced Ulcerative colitis in mice and its preliminary molecular mechanisms. Int Immunopharmacol. 2024 Mar 30;130:111757. doi: 10.1016/j.intimp.2024.111757. (中科院2区 TOP)

5. Liu Z, Nong K, Qin X, Fang X, Zhang B, Chen W, Wang Z, Wu Y, Shi H, Wang X, Liu Y, Guan Q, Zhang H. The antimicrobial peptide Abaecin alleviates colitis in mice by regulating inflammatory signaling pathways and intestinal microbial composition. Peptides. 2024 Mar;173:171154. doi: 10.1016/j.peptides.2024.171154.

6. Liu Z, Qin X, Nong K, Fang X, Zhang B, Chen W, Wang Z, Wu Y, Shi H, Wang X, Zhang H. Oral administration of LfcinB alleviates DSS-induced colitis by improving the intestinal barrier and microbiota. Food Funct. 2024 Feb 19;15(4):2038-2051. doi: 10.1039/d3fo05236b. (中科院1区 TOP)

7. Xinyun Qin, Keyi Nong, Zhineng Liu, Xin Fang, Bin Zhang, Wanyan Chen, Zihan Wang, Yijia Wu, Huiyu Shi, Xuemei Wang, Haiwen Zhang. Regulation of the intestinal flora using polysaccharides from Callicarpa nudiflora Hook to alleviate ulcerative colitis and the molecular mechanisms involved, Int J Biol Macromol, 2023 Dec 19;258(Pt 1):128887. doi: 10.1016/j.ijbiomac.2023.128887. (中科院1区 TOP)

8. Xin Fang, Keyi Nong, Xinyun Qin, Zhineng Liu, Feng Gao, Yuanli Jing, Haokai Fan, Zihan Wang, Xuemei Wang, Haiwen Zhang. Effect of purple sweet potato-derived anthocyanins on heat stress response in Wenchang chickens and preliminary mechanism study, Poultry Science, 2023 Sep;102(9):102861. doi: 10.1016/j.psj.2023.102861. (中科院1区 TOP)

9. Xinyun Qin, Zhineng Liu, Keyi Nong, Xin Fang, Wanyan Chen, Bin Zhang, Yijia Wu, Zihan Wang, Huiyu Shi, Xuemei Wang, Haiwen Zhang. Porcine-derived antimicrobial peptide PR39 alleviates DSS-induced colitis via the NF-κB/MAPK pathway, Int Immunopharmacol, 2023 Dec 18:127:111385. doi: 10.1016/j.intimp.2023.111385. (中科院2区 TOP)

10. Haiwen Zhang, Liangmin Huang, Shihui Hu, Xinyun Qin, Xuemei Wang. Moringa oleifera Leaf Powder as New Source of Protein-Based Feedstuff Improves Growth Performance and Cecal Microbial Diversity of Broiler Chicken, Animals, 2023 Mar 20;13(6):1104. doi: 10.3390/ani13061104. (中科院2区)

11. Keyi Nong 1, Youming Liu 1, Xin Fang 1, Xinyun Qin 1, Zhineng Liu 1, Haiwen Zhang. Effects of the Vitamin D3 on Alleviating the Oxidative Stress Induced by Diquat in Wenchang Chickens, Animals, 2023 Feb 17;13(4):711. doi: 10.3390/ani13040711. (中科院2区)

12. H. Zhang; Y. Liu;X. Fang;L. Gu;C. Luo;L. Chen and Q. Wang; Vitamin D3 Protects Mice from Diquat-Induced Oxidative Stress through the NF-kappaB/Nrf2/HO-1 Signaling Pathway, Oxidative medicine and cellular longevity, 2021, 2021: 6776956. (中科院2区)

13. Di, ZH; Zheng, JP; Zhang, HW; Wang, X; Guo, GY; Lin, YQ; Han, Q; Li, RS; Yang, N; Fan, LX; Zeng, JF. Natural outbreaks and molecular characteristics of Streptococcus agalactiae infection in farmed American bullfrog (Rana catesbeiana), Aquaculture, 2022, DOI 10.1016/j.aquaculture.2021.737885. (中科院1区 TOP)

14. Zhang Haiwen, Hua Rui, Zhang Bingxi, Guan Qingfeng, Zeng Jifeng, Wang Xuemei, Wang Beibei. Oral Administration of Bovine Lactoferrin-Derived Lactoferricin(Lfcin) B Could Attenuate Enterohemorrhagic Escherichia coli O157:H7 Induced Intestinal Disease through Improving Intestinal Barrier Function and Microbiota. J. Agric. Food Chem.DOI: 10.1021/acs.jafc.9b00861. (中科院1区 TOP)

15. Haiwen Zhang, Bingxi Zhang, Xiaomeng Zhang, Xuemei Wang, Kebang Wu, Qingfeng Guan. Effects of cathelicidin-derived peptide from reptiles on lipopolysaccharide-induced intestinal inflammation in weaned piglets. Vet Immunol Immunopathol. 2017, Oct; 192:41-53. doi: 10.1016/j. (中科院3区)

16. Zhang haiwen, Hua rui, Zhang bingxi, Guan qingfeng, Wang Beibei, Zeng jifeng, Wang xuemei, Wu kebang. Cathelicidin-derived PR39 protects enterohemorrhagic Escherichia coli O157:H7 challenged mice by improving epithelial function and balancing the microbiota in the intestine. Sci Rep. 2019 Jul 1;9(1):9456. (中科院3区)

17. Zhang haiwen, Hua rui, Zhang bingxi, Zhang xiaomeng, Yang hui, Zhou xihong. Serine Alleviates Dextran Sulfate Sodium-Induced Colitis and Regulates the Gut Microbiota in Mice. Front Microbiol. 2018 Dec 10;9:3062. (中科院2区 TOP)

18. Haiwen, Zhang, Xi Xia, Feifei Han, Qin Jiang, Yili Rong, Deguang Song, and Yizhen Wang. Cathelicidin-BF, a novel antimicrobial peptide from Bungarus fasciatus, attenuates disease in a dextran sulfate sodium model of colitis. Mol Pharm. 2015, 12 (5): 1648–1661. (中科院2区)

19. Feifei Han, Haiwen Zhang (co-first author), Xi Xia, Haitao Xiong, Deguang Song, Xin Zong, and Yizhen Wang. Porcine beta-defensin 2 attenuates inflammation and mucosal lesions in dextran sodium sulfate-induced colitis. J Immunol. 2015, 194(4): p. 1882-93. (中科院2区 TOP)

20. Tao Chen, Shihui Hu, Haiwen Zhang*（co-corresponding author）, Qingfeng Guan, Yuhui Yang, Xuemei Wang*. 2017. Anti-inflammatory effects of Dioscorea alata L.anthocyanins in a TNBS-induced colitis model. Food & Function. DOI: 10.1039/c6fo01273f. (中科院1区 TOP)

21. Chao Luan, Haiwen Zhang, Deguang Song, Yonggang Xie, Jie Feng, and Yizhen Wang. Expressing antimicrobial peptide cathelicidin-BF in Bacillus subtilis using SUMO technology. Appl Microbiol Biotechnol. 2014, 98(8):p.3651-58.

22. Deguang Song, Xin Zong, Haiwen Zhang, Tenghao Wang, Hongbo Yi, Chao Luan, and Y. Wang. Antimicrobial peptide Cathelicidin-BF prevents intestinal barrier dysfunction in a mouse model of endotoxemia. Int Immunopharmacol. 2015, 25(1): p. 141-7.

23. Hongbo Yi, Caihua Yu, Haiwen Zhang, Denghu Jiang, Yizhen Wang. Cathelicidin-BF suppresses intestinal inflammation by inhibiting the nuclear factor-κB signaling pathway and enhancing the phagocytosis of immune cells via STAT-1 in weanling piglets. Int Immunopharmacol. 2015, 28 (1) : p. 61–69.

24. Yonggang Xie, Chao Luan, Haiwen Zhang, Feifei Han, Jie Feng, Y.J. Choi, D. Groleau, and Yizhen Wang. Effects of thioredoxin: SUMO and intein on soluble fusion expression of an antimicrobial peptide OG2 in Escherichia coli. Protein Pept Lett. 2013, 20(1): p. 54-60. IF=1.994

25. Yonggang Xie, Feifei Han, Chao Luan, Haiwen Zhang, Jie Feng, Choi YJ, Groleau D, Yizhen Wang. High-Yield Soluble Expression and Simple Purification of the Antimicrobial Peptide OG2 Using the Intein System in Escherichia coli. BioMed Research International. 2013: 754319.

26. Chao Luan, Yonggang Xie, Yutian Pu , Haiwen Zhang, Feifei Han, Jie Feng, and Yizhen Wang. Recombinant expression of antimicrobial peptides using a novel self-cleaving aggregation tag in Escherichia coli. Can J Microbiol. 2014, 60(3): p. 113-20.

27. Yili Rong, Zeqing Lu, Haiwen Zhang, Yizhen Wang*. Effects of Casein glycomacropeptide supplementation on Escherichia coli K88 challenged piglets. Animal nutrition. 2015.

28. Xinxia Wang, Yizhen Wang, Yongjin Li, Ming Huang, Yang Gao, Xianfeng Xue, Haiwen Zhang. Responses of yellow catfish (Pelteobagrus fulvidraco) to different dietary concentrations of aflatoxin B1 (AFB1) and evaluation of an aflatoxin binder in offsetting its negative effects. Ciencias Marinas. 2016.

29. Qin Jiang, Haiwen Zhang, Yonggang Xie, Yizhen Wang. Recombinant expression of porcine lactoferrin peptide LF-6 with intein technology and its immunomodulatory function in ETEC K88-infected mice. Int Immunopharmacol. 2016, 39(1): p. 181-191.

30. Feifei Han, Zeqing Lu, Yifan Liu, Xi Xia, Haiwen Zhang, Yizhen Wang. Cathelicidin-BF ameliorates lipopolysaccharide-induced intestinal epithelial barrier disruption in rat. Life Science. 2016, 152(1): p. 199-209.

31. Chen Wanyan#; Zhang Bin#; Nong Keyi; Lang Wen; Qin Xinyun; Liu Zhineng; Yang Zheng; Chen Tingyu; Cao Ruixue; Shi Huiyu; Li Lianbin; Wang Xuemei; Zhang Haiwen*; Callicarpa nudiflora Hook polysaccharides improve lipopolysaccharide-induced small intestinal injury by modulating gut microbiota metabolism and inhibiting NF-κB/MAPK signaling, International Journal of Biological Macromolecules, 2025, 17:149763. (中科院2区 TOP)

32. Zhang Bin^#; Chen Wanyan^#; Qin Xinyun^#; Liu Zhineng; Yang Zheng; Lang Wen; Nong Keyi; Shi Huiyu; Li Lianbin; Wang Xuemei; Liu Xiande^*; Zhang Haiwen^*; Porcine-derived PR39 antimicrobial peptide alleviates lipopolysaccharide-induced intestinal inflammatory injury in mice by modulating NF-κB/MAPK signaling pathway and intestinal flora, International Immunopharmacology, 2025, 115818. (中科院2区 TOP)

另以第一或通讯作者发表中文核心期刊论文30篇（略）。

出版著作

1.《动物营养与免疫学概论》，中国农业科学技术出版社，10万字；

2.《生物技术与工程原理及应用》，中国原子能出版社，7万字。

另作为主要成员参与编写书籍2部。

获得荣誉

海南省科协青年托举人才；海南省科技特派员；永利yl7703主页优秀班主任；永利yl7703主页优秀学业导师。

教学和研究生培养

主讲本科生课程《实验动物学》《专业英语》《畜牧业经济管理》《动物毒理学》等；主讲研究生课程《专业前沿讨论课程》《动物营养与饲料学》《生物信息学》等。先后培养研究生7名，在读研究生8名。

社会兼职

海南省地方鸡产业体系核心成员；海南省畜牧兽医协会会员；海南省生态协会会员；海南省免疫协会会员

招生专业

畜牧学专业（硕/博）、兽医学专业（硕/博）、生物学专业（博）。