研究成果 | 科研项目 1.国家自然科学基金委,地区基金项目:32560858,多杀性巴氏杆菌感染条件下山羊JMJD3去甲基化调控肺巨噬细胞极化的机制研究,2026-01至2029-12,32万元,在研。 2.海南省科技厅,高层次人才项目,324RC447,多杀性巴氏杆菌感染条件下海南黑山羊SAA3的作用机制,2024-03至2027-02,10万元,在研。 3.海南省科技厅,青年基金项目,321QN0860,基于ATAC技术解析多杀性巴氏杆菌感染山羊支气管上皮细胞的转录组调控机制研究,2021-12-23 至2024-09-30,5万元,结题。 4.海南省教育厅,高等学校科研项目,Hnky2021-1,多杀性巴氏杆菌引起的海南黑山羊呼吸道疾病机制的研究,2021-01至2023-12,1.5万元,结题。 5.海南省科技厅,重点研发项目子课题,ZDYF2021XDNY174,海南黑山羊优质核心群构建与快速扩繁,2021-09-01至2023-09-01,10万元,结题。 学术论文 1.Wang Z, Wu L, Qian H, Fu Y, Chen T, Du L, Gao H, Chen S, Wang F, Chen Q*. PBMCs of Hainan Black goats mediating immune response to resist the infection of Mannheimia haemolytica. Microb Pathog. 2026 Jan;210:108183. 2.Yang Y, Chen X, Wang Z, Wu L, Du L, Gao H, Chen S, Chen Q*, Wang F*. Dysregulated interferon signaling and hyperinflammation upon FCGBP knockdown in goat bronchial epithelial cells infected with Pasteurella multocida. Front Vet Sci. 2026 Mar 2;13:1761935. 3.Zhang Z, Chen X, Meng Y, Jiang J, Wu L, Chen T, Pan H, Jiao Z, Du L, Man C, Chen S, Wang F, Gao H, Chen Q*. Up-Regulation of S100A8 and S100A9 in Pulmonary Immune Response Induced by a Mycoplasma capricolum subsp. capricolum HN-B Strain. Animals (Basel). 2024 Jul 14;14(14):2064. 4.Meng Y, Zhang W, Cheng Y, Wu Y, Wu H, He M, Chen S, Man C, Gao H, Du L, Chen Q*, Wang F*. Development and verification of a 10K liquid chip for Hainan black goat based on genotyping by pinpoint sequencing of liquid captured targets. BMC Genom Data. 2024 May 7;25(1):44. 5. Chen Q, Chai Y, Zhang W, Cheng Y, Zhang Z, An Q, Chen S, Man C, Du L, Zhang W, Wang F*. Whole-Genome Sequencing Reveals the Genomic Characteristics and Selection Signatures of Hainan Black Goat. Genes (Basel). 2022 Aug 26;13(9):1539. 6. Zhang W, Jiao Z, Huang H, Wu Y, Wu H, Liu Z, Zhang Z, An Q, Cheng Y, Chen S, Man C, Du L, Wang F, Chen Q*. Effects of Pasteurella multocida on Histopathology, miRNA and mRNA Expression Dynamics in Lung of Goats. Animals (Basel). 2022 Jun 13;12(12):1529. 7. Li H, He M, Cheng Y, Jiang J, Yang W, Zhang Z, An Q, Chen S, Man C, Du L, Wang F, Chen Q*. Up-Regulation of Interleukin-10 in Splenic Immune Response Induced by Serotype A Pasteurella multocida. Genes (Basel). 2022 Sep 3;13(9):1586. 8. An Q, Chen S, Zhang L, Zhang Z, Cheng Y, Wu H, Liu A, Chen Z, Li B, Chen J, Zheng Y, Man C, Wang F, Chen Q*, Du L*. The mRNA and miRNA profiles of goat bronchial epithelial cells stimulated by Pasteurella multocida strains of serotype A and D. PeerJ. 2022, 10: e13047. 9. Zhang, Z.; Jiang, J.; He, M.; Li, H.; Cheng, Y.; An, Q.; Chen, S.; Du, L.; Man, C.; Chen, Q.*; Li, L.*; Wang, F*. First Report and Comparative Genomic Analysis of a Mycoplasma mycoides Subspecies capri HN-A in Hainan Island. Microorganisms 2022, 10, 1908. 10. Zhang Z, He M, Jiang J, Li X, Li H, Zhang W, Chen S, Du L, Man C, Chen Q*, Gao H*, Wang F*. First Report and Comparative Genomic Analysis of Mycoplasma capricolum subsp. capricolum HN-B in Hainan Island, China. Microorganisms. 2022 Nov 19;10(11):2298. 11.Chen Q, Chen Z, Zhang Z, Pan H, Li H, Li X, An Q, Cheng Y, Chen S, Man C, Du L, Wang F. Profiling Chromatin Accessibility Responses in Goat Bronchial Epithelial Cells Infected with Pasteurella multocida. Int J Mol Sci. 2023 Jan 9;24(2):1312. 12.Yang X, Fu Q, Zhang W, An Q, Zhang Z, Li H, Chen X, Chen Z, Cheng Y, Chen S, Man C, Du L, Chen Q*, Wang F*. Overexpression of Pasteurella multocida OmpA induces transcriptional changes and its possible implications for the macrophage polarization. Microb Pathog. 2023 Oct;183:106212. 13.吴艳茹,陈巧玲*,刘志勇,李崇瑞,黄惠娴,翟哲,王雪梅,满初日嘎,杜丽,王凤阳.多杀性巴氏杆菌脂多糖刺激羊支气管上皮细胞后的转录组测序与分析[J].中国预防兽医学报,2022,44(07):704-711+717. 14.吴昊天,满初日嘎,王凤阳,李昌,金宁一,陈巧玲*.小反刍兽疫流行状况及分子诊断技术研究现状[J].动物医学进展,2022,43(01):122-126. 15.黄惠娴, 陈巧玲*, 王雪梅, 蒋俊明, 刘志勇, 陈思, 王凤阳, 杜丽. 多杀性巴氏杆菌感染小鼠肝脏转录组分析[J].中国动物传染病学报. 2021, 1-15. 16.张振兴, 陈珍, 刘昂, 程逸文, 陈思, 杜丽, 满初日嘎, 王凤阳, 陈巧玲*. 一株羊源A型多杀性巴氏杆菌的全基因组测序及生物学特性分析[J]. 微生物学通报. 2021, 48(11):4061-4074. 17.陈珍, 张振兴, 陈巧玲*, 程逸文, 陈思, 满初日嘎, 杜丽, 王凤阳. 一株山羊源D型多杀性巴氏杆菌的全基因组测序及生物学特性分析[J].中国动物传染病学报. 2021, 1-13. 18. Qiaoling Chen, Chao Tong, Shaoyang Ma, Luoxiong Zhou, Lili Zhao and Xin Zhao*. Involvement of MicroRNAs in Probiotics-Induced Reduction of the Cecal Inflammation by Salmonella Typhimurium. Frontiers in Immunology. 2017, 8: 704. 19. Mohsen Pourabedin†, Qiaoling Chen†, MingMing Yang and Xin Zhao*. Mannan- and xylooligosaccharides modulate caecal microbiota and expression of inflammatory-related cytokines and reduce caecal Salmonella Enteritidis colonisation in young chickens. FEMS Microbiol Ecol. 2017, 93(1): fiw226. 20. Tong Chao, Chen Qiaoling, Zhao Lili, Ma Junfei, Ibeagha-Awemu EM and Zhao Xin*. Identification and characterization of long intergenic noncoding RNAs in bovine mammary glands. BMC Genomics. 2017,18(1): 468. 授权专利 1.王凤阳;陈巧玲;陈思;满初日嘎,张文灿;侯思梦;杜丽,2023-07-04,中国,ZL202210528454.0(第二完成人)
|