研究成果 | 科研项目 1.国家自然科学基金委员会，青年项目，32202631，ATG16L2在绵羊免疫布病疫苗（S2株）条件下的功能及其作用机制研究，2023.01-2025.12，30万元，主持。 2.海南省自然科学基金，高层次人才项目，2019RC123，山羊MBL2基因抗细菌感染功能的分子机制研究，2020.01-2022.12，10万元，主持。 3.参与国家级项目 3项 学术论文 1. Huan Wang, Mengqi Zhang, Hejie Qian, Taoyu Chen, Yong Meng, Shiyuan Li, Shihua Niu, Churiga Man, Hongyan Gao, Qiaoling Chen, Li Du, Fengyang Wang*, Si Chen*, SMAD5 Regulates Hainan Black Goat ATG16L2 Gene Transcription in Primary Goat Fibroblasts, Journal of Animal Science, 2026;skag089. 2. Zhang Yu, Zhang Zhenxing, Wang Ziying, Chen Yimei, Liao Lianjie, Du Li, Gao Hongyan, Chen Qiaoling, Man Churiga, Chen Si*, Wang Fengyang*. Whole Genome Sequencing and Comparative Genomics Analysis of Goat-Derived Klebsiella oxytoca [J]. Genes (Basel), 2024, 16(1): 13. 3. Wang Huan†, Wu Hui†, Zhang Wencan, Jiang Junming, Qian Hejie, Man Churiga, Gao Hongyan, Chen Qiaoling, Du Li, Chen Si*, Wang Fengyang*. Development and validation of a 5K low-density SNP chip for Hainan cattle [J]. BMC Genomics, 2024, 25(1): 873. 4. Jiao Zizhuo, Jiang Junming, Meng Yong, Wu Guansheng, Tang Jiayang, Chen Taoyu, Fu Yujing, Chen Yuanyuan, Zhang Zhenxing, Gao Hongyan, Man Churiga, Chen Qiaoling, Du Li, Wang Fengyang*, Chen Si*. Immune Cells in the Spleen of Mice Mediate the Inflammatory Response Induced by Mannheimia haemolytica A2 Serotype [J]. Animals, 2024, 14(2): 317. 5. Fu Yujing, Meng Yong, Qian Hejie, Chen Taoyu, Chen Xiangying, Chen Qiaoling, Gao Hongyan, Man Churiga, Du Li, Chen Si*, Wang Fengyang*. Pasteurella multocida Serotype D Infection Induces Activation of the IL-17 Signaling Pathway in Goat Lymphocytes [J]. Microorganisms, 2024, 12(12): 2618. 6. Fu Qiaoyu, Jiang Junming, Li Xubo, Zhai Zhe, Wang Xuemei, Li Chongrui, Chen Qiaoling, Man Churiga, Du Li, Wang Fengyang*, Chen Si*. Activation of MyD88-Dependent TLR Signaling Modulates Immune Response of the Mouse Heart during Pasteurella multocida Infection [J]. Microorganisms, 2023, 11(2): 400. 7. Chen Si, Chen Yuanyuan, Jiao Zizhuo, Wang Chengqiang, Zhao Dantong, Liu Yongbin, Zhang Wenguang, Zhao Shihua, Yang Bin, Zhao Qinan, Fu Shaoyin, He Xiaolong, Chen Qiaoling, Man Churiga, Liu Guoying, Wei Xuefeng, Du Li*, Wang Fengyang*. Clearance of bacteria from lymph nodes in sheep immunized with Brucella suis S2 vaccine is associated with M1 macrophage activation [J]. Veterinary Research, 2023, 54(1): 12. 8. Chen Si, Chang Chencheng, Cui Ke, Yang Weijie, Li Boling, Ni Shiheng, Zhang Wencan, Li Shiyuan, Li Xubo, Wu Guansheng, Li Lianbin, Chen Qiaoling, Man Churiga, Du Li, Zhang Wenguang*, Wang Fengyang*. Whole-genome analyses reveal the genomic diversity and selection signatures of Hainan cattle [J]. Livestock Science, 2023, 275: 105311. 9. He Meirong, Li Haoyang, Zhang Zhenxing, Jiang Junming, Li Hong, Yang Weijie, Cheng Yiwen, Gao Hongyan, Chen Qiaoling, Du Li, Chen Si*, Man Churiga, Wang Fengyang*. Microbiological Characteristics and Pathogenesis of Klebsiella pneumoniae Isolated from Hainan Black Goat [J]. Veterinary Sciences, 2022, 9(9): 471. 10. Chen Si, Wang Chengqiang, Chen Qiaoling, Zhao Dantong, Liu Yongbin, Zhao Shihua, Fu Shaoyin, He Xiaolong, Yang Bin, Zhao Qinan, An Qi, Zhang Zhenxing, Cheng Yiwen, Man Churiga, Liu Guoying, Wei Xuefeng, Zhang Wenguang, Du Li*, Wang Fengyang*. Downregulation of Three Novel miRNAs in the Lymph Nodes of Sheep Immunized With the Brucella suis Strain 2 Vaccine [J]. Frontiers In Veterinary Science, 2022, 9: 15. 11. Li Baobao†, Chen Si†, Wang Chengqiang, Chen Qiaoling, Man Churiga, An Qi, Zhang Zhenxing, Liu Zhiyong, Du Li, Wang Fengyang*. Integrated mRNA-seq and miRNA-seq analysis of goat fibroblasts response to Brucella Melitensis strain M5-90 [J]. Peerj, 2021, 9: e11679. |
